Three Deck View of NCI Fermentation Plant

Three Deck View of NCI Fermentation Plant

In this three deck view of a National Cancer Institute (NCI) Fermentation Plant numerous insulated cooling water, chilled water, and steam pipes are visible as well as electrical conduit. The largest of the fermenters, a 12,000 liter, (not visible due to piping) projects 1 meter above the top level and down through the middle level to 2 meters above the bottom level. The two 1,200 liter fermenters also project down through the top level to 2 meters above the middle level.

In the lower right an elevator is visible which is used to service the three levels. At lower left is the "plumbing panel", an array of insulated piping, large valves, and air lines, used to operate the 12,000 liter fermenter (4, 12, 68, 73, 136, 230).


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Exhaust Filters for the 12,000 Liter Fermenter

Exhaust Filters for the 12,000 Liter Fermenter

The round cylindrical head jutting up through the floor, actually 1 meter in height and 40 cm in diameter, is the primary exhaust filter used during all fermentations. The square head jutting up through the floor, also 1 meter in height and 40 cm square is the secondary exhaust filter used only on occasion of failure of the primary due to clogging. If the primary exhaust filter is clogged by foam (which contains medium and mycelium) the exhaust air has no where to escape and builds up pressure in the fermenter to dangerous levels. The secondary exhaust filter is then used after appropriate measures have been taken to reduce the foam level. This prevents "blow out" of a rupture disk due to over pressurization of the fermenter (14, 68, 73, 98, 230, 258).



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Craig Bremmon
CEBTech Services
503 11 th Ave. SE, Suite 5
Aberdeen, SD 57401

bremm001@nvc.net
Phone: 605 226-3595
Mobile: 605 377-4062
Fax: 605 226-3595